Endocrine Abstracts

Introduction: Chronic hypercortisolemia during Cushing Syndrome (CS) determines significant changes in the plasticity and function of metabolic tissues like visceral adipose tissue (VAT). Persistence of alterations in VAT function after CS remission is under debate, as data of clinical studies is not consistent due to confounder factors and limited availability of VAT. Animal model of reversible CS presents long-term alterations on VAT after remission. We investigate VAT alter...

Introduction: Active hypercortisolism of Cushing syndrome (CS) determines major changes in the plasticity and function of metabolic key target tissues as the adipose tissue (AT). Persistence of target tissue altered metabolic memory after the cure/remission of Cushing syndrome is still at debate as clinical observational studies are limited due to confounder factors both in endogenous as exogenous CS. We postulate that after remission of hypercortisolism, adipose tissue (AT) p...